Prefrontal cortex glutamate afferents are essential for acute and chronic effects of Ritalin

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Prefrontal cortex glutamate afferents are essential for acute and chronic effects of Ritalin

Background Progressive augmentation of behavioral response following repeated psychostimulant administrations is known as behavioral sensitization, and is an experimental indicator of a drug’s liability for abuse (Robinson and Berridge, 1993; Dafny and Yang, 2006). It is known that Ritalin or methylphenidate (MPD), a drug used to treat Attention-Deficit Hyperactivity Disorder (ADHD), induces se...

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Prefrontal cortex glutamate and extraversion.

Extraversion is considered one of the core traits of personality. Low extraversion has been associated with increased vulnerability to affective and anxiety disorders. Brain imaging studies have linked extraversion, approach behaviour and the production of positive emotional states to the dorsolateral prefrontal cortex (DLPFC) and glutamatergic neurotransmission. However, the relationship betwe...

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Acute Effects of Ecstasy on Memory Are more Extensive than Chronic Effects

Introduction: Exposure to 3, 4- methylenedioxymethamphetamine (MDMA) could lead to serotonergic system toxicity in the brain. This system is responsible for learning and memory functions. Studies show that MDMA causes memory impairment dose-dependently and acutely. The present study was designed to evaluate the chronic and acute effects of MDMD on spatial memory and acquisition of passive avoid...

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Chronic Ritalin Administration during Adulthood Increases Serotonin Pool in Rat Medial Frontal Cortex

Background: Ritalin has high tendency to be abused. It has been the main indication to control attention deficit hyperactivity disorder. The college students may seek for it to improve their memory, decrease the need for sleep (especially during exams), which at least partially, can be related to serotonergic system. Therefore, it seems worthy to evaluate the effect of Ritalin intake on mature ...

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ژورنال

عنوان ژورنال: Annals of General Psychiatry

سال: 2010

ISSN: 1744-859X

DOI: 10.1186/1744-859x-9-s1-s88